KIAA1369

Synonym(s):HCR;HRI;Heme-controlled repressor;EIF2AK1;Eukaryotic translation initiation factor 2-alpha kinase 1

Molecular Weight: 0
Update Date: 2026-01-13 11:26:45

What is KIAA1369?

General Description

Eukaryotic translation initiation factor 2-α kinase 1 (EIF2AK1) or HRI is a kinase that can be inactivated by hemin. The gene encoding this protein is localized on human chromosome 7p22.1.

Biochem/physiol Actions

Eukaryotic translation initiation factor 2-α kinase 1 (EIF2AK1) modulates protein synthesis. It acts at the level of translation initiation to downregulate protein synthesis in response to stress. The protein is activated by heme deficiency and other stimuli and is a major protein kinase that phosphorylates EIF2-α. EIF2AK1 is downregulated in the majority of ovarian cancers compared with normal ovarian tissues. It functions in iron homeostasis and may play a role in hemolytic and inflammatory anemia.

Properties of KIAA1369

storage temp.	-20°C
form	buffered aqueous glycerol solution

Safety information for KIAA1369

Computed Descriptors for KIAA1369

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