KF 17837

CAS NO.：152881-18-0
Empirical Formula: C20H26N4O4
Molecular Weight: 386.44
MDL number: MFCD22493499
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-05 11:31:08

What is KF 17837?

Description

KF 17837S is an adenosine A(2a) receptor antagonists, which is potential therapeutic and neuroprotective effects in Parkinson's disease.

in vitro

The novel A2A receptor antagonist, (E)-8-(3,4-dimethoxystyryl)-1,3-dipropyl-7-methylxanthine (KF 17837), blocked the CGS 21680 (1 nM)-induced inhibition of [3H]-GABA efflux with an EC50 of approximately 30 nM and also antagonized the CGS 21680 (0.1 nM)-induced stimulation of [3H]-ACh release with an EC50 of approximately 0.3 nM._x000D_ _x000D_ Reference: Br J Pharmacol. 1994 Sep;113(1):43-8. https://pubmed.ncbi.nlm.nih.gov/7812630/

in vivo

Autoradiographic study of [3H]KF17837S binding using rat brain sections revealed that the binding site was highly enriched in the striatal region. These data indicate that [3H] KF17837S labels the adenosine A2A receptor in rat brain._x000D_ _x000D_ Reference: Mol Pharmacol. 1994 Nov;46(5):817-22. https://pubmed.ncbi.nlm.nih.gov/7969067/

Properties of KF 17837

Boiling point:	567.2±60.0 °C(Predicted)
Density	1.24±0.1 g/cm3(Predicted)
pka	-0.24±0.70(Predicted)

Safety information for KF 17837

Computed Descriptors for KF 17837

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