Keap1–Nrf2-IN-1
- CAS NO.：2232112-72-8
- Empirical Formula: C24H24N2O7S
- Molecular Weight: 484.52
- Update Date: 2023-05-21 10:59:17
What is Keap1–Nrf2-IN-1?
Description
Keap1-Nrf2 IN-1 (compound35) is a Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interaction inhibitor, and with an IC50 of 43 nM for Keap1 protein. Keap1-Nrf2 IN-1 (compound35) activates Nrf2-regulated cytoprotective response and antagonizes acetaminophen-induced liver injury both in cellular and in vivo models[1]. IC50: 43 nM (Keap1 protein)[1]
References
[1]. Lu MC, et al. Discovery of a Potent Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitor with Natural Proline Structure as a Cytoprotective Agent against Acetaminophen-Induced Hepatotoxicity. J Med Chem. 2019 Jul 25;62(14):6796-6813.
Properties of Keap1–Nrf2-IN-1
| Boiling point: | 784.5±70.0 °C(Predicted) |
| Density | 1.454±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 2.11±0.20(Predicted) |
Safety information for Keap1–Nrf2-IN-1
Computed Descriptors for Keap1–Nrf2-IN-1
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