Keap1–Nrf2-IN-1

CAS NO.：2232112-72-8
Empirical Formula: C24H24N2O7S
Molecular Weight: 484.52
Update Date: 2026-04-24 14:58:35

What is Keap1–Nrf2-IN-1?

Description

Keap1-Nrf2 IN-1 (compound35) is a Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interaction inhibitor, and with an IC50 of 43 nM for Keap1 protein. Keap1-Nrf2 IN-1 (compound35) activates Nrf2-regulated cytoprotective response and antagonizes acetaminophen-induced liver injury both in cellular and in vivo models[1]. IC50: 43 nM (Keap1 protein)[1]

References

[1]. Lu MC, et al. Discovery of a Potent Kelch-Like ECH-Associated Protein 1-Nuclear Factor Erythroid 2-Related Factor 2 (Keap1-Nrf2) Protein-Protein Interaction Inhibitor with Natural Proline Structure as a Cytoprotective Agent against Acetaminophen-Induced Hepatotoxicity. J Med Chem. 2019 Jul 25;62(14):6796-6813.

Properties of Keap1–Nrf2-IN-1

Boiling point:	784.5±70.0 °C(Predicted)
Density	1.454±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
pka	2.11±0.20(Predicted)

Safety information for Keap1–Nrf2-IN-1

Computed Descriptors for Keap1–Nrf2-IN-1

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