KEA1-97

Synonym(s):4,6-Dichloro-N-(4′-fluoro-[1,1′-biphenyl]-4-yl)-1,3,5-triazin-2-amine

CAS NO.：2138882-71-8
Empirical Formula: C15H9Cl2FN4
Molecular Weight: 335.16
MDL number: MFCD31697744
Update Date: 2025-12-03 18:03:33

What is KEA1-97?

Description

KEA1-97 is a Thioredoxin-Caspase 3 interaction disruptor. It was found to target lysine 72 of thioredoxin, inhibiting its interactions with caspase 3 and inducing apoptosis without affecting other thioredoxin activity. KEA1-97 induced apoptosis in breast cancer cells and treatment of immune-deficient SCID mice at 5 mg/kg ip impaired breast tumor xenograft growth.

Properties of KEA1-97

Boiling point:	530.3±52.0 °C(Predicted)
Density	1.466±0.06 g/cm3(Predicted)
storage temp.	4°C, protect from light
solubility	DMSO : 100 mg/mL (298.36 mM; Need ultrasonic)
pka	0.57±0.10(Predicted)
form	Solid
color	White to light yellow

Safety information for KEA1-97

Computed Descriptors for KEA1-97

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