KDU691

CAS NO.：1513879-19-0
Empirical Formula: C22H18ClN5O2
Molecular Weight: 419.86
Update Date: 2026-04-21 10:31:43

What is KDU691?

Description

KDU691 is an antimalarial compound. It inhibits recombinant P. vivax phosphatidylinositol 4-kinase (PI4K) with an IC₅₀ value of 1.5 nM. KDU691 is selective for P. vivax PI4K over recombinant human PI4KβIII and PI3Kα, -β, -γ, and -δ (IC₅₀s = 7.9, 8.8, 2.4, 8, and 3.4 μM, respectively), as well as VPS34 (IC₅₀ = >9.7 μM) and 36 additional kinases in a panel of lipid and protein kinases (IC₅₀s = >10 μM). It is active against P. falciparum and P. yoelii schizonts (IC₅₀s = 0.06 and 0.04 μM, respectively), as well as P. cynomolgi schizonts and hypnozoites (IC₅₀s = 0.11 and 0.2 μM, respectively). KDU691 completely prevents, but does not eradicate established, P. cynomolgi infection in rhesus monkeys when administered at a dose of 20 mg/kg.

The Uses of KDU691

KDU691, is a PI4K inhibitor.

Properties of KDU691

Density	1.35±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:PBS (pH 7.2) (1:9):0.1(Max Conc. mg/mL);0.24(Max Conc. mM) Ethanol:10.0(Max Conc. mg/mL);23.82(Max Conc. mM)
form	A crystalline solid
pka	14.59±0.46(Predicted)
color	White to off-white

Safety information for KDU691

Computed Descriptors for KDU691

New Products

2-(2-Chlorophenyl)glycine Propiolic Acid 1-(3-Hydroxy-4-methoxyphenyl)-2-nitroethene (±)-amino(2-fluorophenyl)acetic acid trans-3-Benzyloxy-4-methoxy-beta-nitrostyrene 1-Pentadecanol 2,4-Dihydroxybenzaldehyde Dipropyl disulfide Pyrrolo[1,2-a]pyrimidine-6-carboxylic acid, 4,6,7,8-tetrahydro-4-oxo-, sodium salt (1:1), (6S) Obidoxime hydrochloride API 4 pentyn 1 ol N-Vinylformamide Methacrylate-PEG-Methacrylate, Mn:35000 2,4-Dihydroxyacetophenone 2-Chloro 5-Fluoro Pyridine Vasicinone 2-Chloroisonicotinic Acid Tween 80 or Polysorbate 80 2-Butyn-1-oL N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamide N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine Pirtobrutinib intd. 2-Pentyn-1-oL 4-Nitrobenzotrifluoride