KDU691

CAS NO.：1513879-19-0
Empirical Formula: C22H18ClN5O2
Molecular Weight: 419.86
Update Date: 2026-04-16 19:33:17

What is KDU691?

Description

KDU691 is an antimalarial compound. It inhibits recombinant P. vivax phosphatidylinositol 4-kinase (PI4K) with an IC₅₀ value of 1.5 nM. KDU691 is selective for P. vivax PI4K over recombinant human PI4KβIII and PI3Kα, -β, -γ, and -δ (IC₅₀s = 7.9, 8.8, 2.4, 8, and 3.4 μM, respectively), as well as VPS34 (IC₅₀ = >9.7 μM) and 36 additional kinases in a panel of lipid and protein kinases (IC₅₀s = >10 μM). It is active against P. falciparum and P. yoelii schizonts (IC₅₀s = 0.06 and 0.04 μM, respectively), as well as P. cynomolgi schizonts and hypnozoites (IC₅₀s = 0.11 and 0.2 μM, respectively). KDU691 completely prevents, but does not eradicate established, P. cynomolgi infection in rhesus monkeys when administered at a dose of 20 mg/kg.

The Uses of KDU691

KDU691, is a PI4K inhibitor.

Properties of KDU691

Density	1.35±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:PBS (pH 7.2) (1:9):0.1(Max Conc. mg/mL);0.24(Max Conc. mM) Ethanol:10.0(Max Conc. mg/mL);23.82(Max Conc. mM)
form	A crystalline solid
pka	14.59±0.46(Predicted)
color	White to off-white

Safety information for KDU691

Computed Descriptors for KDU691

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