Kavain
Synonym(s):trans-5,6-Dihydro-4-methoxy-6-(2-phenylethenyl)-2H-pyran-2-one;DL -Kawain
- CAS NO.：3155-48-4
- Empirical Formula: C14H14O3
- Molecular Weight: 230.26
- MDL number: MFCD00270446
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-15 13:02:44
What is Kavain?
The Uses of Kavain
rac-Kavain is the main kavalactone found in the roots of the kava plant. Kavain is known to exhibit anticonvulsive properties by attenuating vascular smooth muscle contraction through interactions with voltage-dependent sodium and calcium channels. rac-Kavain was shown in recent research to exhibit protective properties on anaerobic glycolysis, ATP content and intracellular calcium and sodium of anoxic brain vesicles.
The Uses of Kavain
anticonvulsant, analgesic, anxiolytic, suppreses excitatory postsynaptic potential
Definition
ChEBI: DL-kavain is https://www.chemicalbook.com/ProductChemicalPropertiesCB9738874_EN.htm It has a role as a glycine receptor antagonist.
Synthesis Reference(s)
The Journal of Organic Chemistry, 41, p. 4070, 1976 DOI: 10.1021/jo00888a004
Properties of Kavain
| Melting point: | 142-148 °C |
| Boiling point: | 432.6±45.0 °C(Predicted) |
| Density | 1.15±0.1 g/cm3(Predicted) |
| storage temp. | Amber Vial, -20°C Freezer, Under inert atmosphere |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | neat |
| form | Solid |
| color | Off-White to Pale Yellow |
| BRN | 177877 |
| Stability: | Light and Moisture Sensitive |
| InChI | InChI=1S/C14H14O3/c1-16-13-9-12(17-14(15)10-13)8-7-11-5-3-2-4-6-11/h2-8,10,12H,9H2,1H3/b8-7+ |
| CAS DataBase Reference | 3155-48-4(CAS DataBase Reference) |
Safety information for Kavain
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Kavain
| InChIKey | XEAQIWGXBXCYFX-BQYQJAHWSA-N |
| SMILES | C1(=O)OC(/C=C/C2=CC=CC=C2)CC(OC)=C1 |
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