KAI407

CAS NO.：1513879-18-9
Empirical Formula: C22H14F3N5O
Molecular Weight: 421.37
Update Date: 2026-05-11 16:31:51

What is KAI407?

Description

KAI407 is a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro. KAI407 showed an activity profile similar to that of primaquine (PQ), efficiently killing the earliest stages of the parasites that become either primary hepatic schizonts or hypnozoites (50% inhibitory concentration [IC50] for hypnozoites, KAI407, 0.69 μM, and PQ, 0.84 μM; for developing liver stages, KAI407, 0.64 μM, and PQ, 0.37 μM). KAI407 may represent a new compound class for P. vivax malaria prophylaxis and potentially a radical cure.

Properties of KAI407

Density	1.35±0.1 g/cm3(Predicted)
pka	1.46±0.30(Predicted)

Safety information for KAI407

Computed Descriptors for KAI407

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