KAHWEOL

CAS NO.：6894-43-5
Empirical Formula: C20H26O3
Molecular Weight: 314.42
MDL number: MFCD00171665
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-27 17:00:41

What is KAHWEOL?

The Uses of KAHWEOL

Kahweol is an antioxidant diterpene contained in unfiltered coffee. Kahweol behaves as an anti-inflammatory and anti-angiogenic compound with potential use in antitumoral therapies. Recent research have demonstrated the ability of Kahweol in inhibiting metastasis by modulating expressions of MMPs and VEGF via STAT3 inactivation.

What are the applications of Application

Kahweol is an inducer of the detoxifying enzyme, glutathione S-transferase

Definition

ChEBI: Kahweol is a diterpenoid with formula C20H26O3, isolated from the beans of Coffea arabica. It exhibits antioxidant, anti-inflammatory, anti-angiogenesis and anti-proliferative properties. It has a role as an angiogenesis inhibitor, an apoptosis inducer, an antioxidant, an anti-inflammatory agent, an antineoplastic agent and a plant metabolite. It is a diterpenoid, a member of furans, an organic heteropentacyclic compound, a tertiary alcohol and a primary alcohol.

Properties of KAHWEOL

Melting point:	88-90℃
Boiling point:	476.6±45.0 °C(Predicted)
Density	1.25±0.1 g/cm3(Predicted)
storage temp.	−20°C
solubility	DMF:5.0(Max Conc. mg/mL);0.64(Max Conc. mM) DMSO:18.17(Max Conc. mg/mL);57.77(Max Conc. mM) Ethanol:5.0(Max Conc. mg/mL);0.64(Max Conc. mM) Ethanol:PBS (pH 7.2) (1:5):0.02(Max Conc. mg/mL);0.06(Max Conc. mM)
pka	14.43±0.40(Predicted)
form	White to off-white solid.
color	Off-white to light yellow