K-604 dihydrochloride

CAS NO.：217094-32-1
Empirical Formula: C23H31ClN6OS3
Molecular Weight: 539.17
Update Date: 2026-01-29 15:22:00

What is K-604 dihydrochloride?

Biological Activity

K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor with IC50 of 0.45±0.06 μM.

in vivo

Using F1B hamsters, an animal model susceptible to diet-induced hyperlipidemia and atherosclerosis, the effects of K-604 dihydrochloride on aortic lesion areas and plasma cholesterol levels are assessed.

Properties of K-604 dihydrochloride

storage temp.	2-8°C
solubility	DMSO: 62.5 mg/mL (108.57 mM)
form	Solid
color	white to beige

Safety information for K-604 dihydrochloride

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for K-604 dihydrochloride

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