K-604 dihydrochloride
- CAS NO.：217094-32-1
- Empirical Formula: C23H31ClN6OS3
- Molecular Weight: 539.17
- Update Date: 2026-04-21 10:31:43
What is K-604 dihydrochloride?
Biological Activity
K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor with IC50 of 0.45±0.06 μM.
in vivo
Using F1B hamsters, an animal model susceptible to diet-induced hyperlipidemia and atherosclerosis, the effects of K-604 dihydrochloride on aortic lesion areas and plasma cholesterol levels are assessed.
Properties of K-604 dihydrochloride
| storage temp. | 2-8°C |
| solubility | DMSO: 62.5 mg/mL (108.57 mM) |
| form | Solid |
| color | white to beige |
Safety information for K-604 dihydrochloride
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for K-604 dihydrochloride
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