JZL 195

Synonym(s):4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 4-nitrophenyl ester

CAS NO.：1210004-12-8
Empirical Formula: C24H23N3O5
Molecular Weight: 433.46
MDL number: MFCD18382122
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-22 18:57:36

What is JZL 195?

Description

Fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) mediate the hydrolysis of the endocannabinoids arachidonoyl ethanolamide (AEA) and 2-arachidonoylglycerol (2-AG), respectively. JZL 195 is a potent inhibitor of both FAAH and MAGL (IC₅₀s = 2 and 4 nM, respectively). It poorly inhibits neuropathy target esterase and ABHD6 and does not inhibit other brain serine hydrolases. JZL 195 displays time-dependent inhibition of FAAH and MAGL in vivo, consistent with a covalent mechanism of activation. The in vivo inhibitory actions of JZL 195 against FAAH and MAGL are comparable to those of the selective inhibitors PF-3845 and JZL 184 , respectively. Through its inhibitory actions, JZL 195 simultaneously augments brain levels of AEA and 2-AG, producing antinociceptive, cataleptic, and hypomotility effects like those produced by direct CB₁ agonists.

The Uses of JZL 195

JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor with IC50 of 13 nM and 19 nM for mouse brain FAAH and MAGL respectively.

Storage

Store at -20°C

Properties of JZL 195

Boiling point:	581.8±50.0 °C(Predicted)
Density	1.303±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	DMSO: ≥5mg/mL at warmed
pka	6.13±0.10(Predicted)
form	powder
color	white to beige

Safety information for JZL 195

Signal word	Warning
Pictogram(s)	Environment GHS09
GHS Hazard Statements	H400:Hazardous to the aquatic environment, acute hazard
Precautionary Statement Codes	P273:Avoid release to the environment.

Computed Descriptors for JZL 195

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