JWH 250 N-(4-hydroxypentyl) metabolite

Description

JWH 250 is a synthetic cannabinoid (CB) which potently activates both CB₁ and CB₂ receptors (K_i values of 11 and 33 nM, respectively).¹ It has been identified in herbal blends.² JWH 250 N-(4-hydroxypentyl) metabolite is expected to be a cytochrome P450 phase I metabolite of JWH 250, detectable both in serum and urine.^3,4,5

The Uses of JWH 250 N-(4-hydroxypentyl) metabolite

JWH-250 4-Hydroxypentyl is a urinary metabolite of JWH-250 (J211500) which acts as cannabinoid receptor 2 agonist.

References

1. Huffman, J.W., Szklennik, P.V., Almond, A., et al. 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles Bioorg. Med. Chem. Lett. 15(18),4110-4113(2005).
2. Kikura-Hanajiri, R., Uchiyama, N., and Goda, Y. Survey of current trends in the abuse of psychotropic substances and plants in Japan Leg. Med. (Tokyo) 13(3),109-115(2011).
3. Wintermeyer, A., M?ller, I., Thevis, M., et al. In vitro phase I metabolism of the synthetic cannabimimetic JWH-018 Anal. Bioanal. Chem. 398(5),2141-2153(2010).
4. Zhang, Q., Ma, P., Cole, R.B., et al. Identification of in vitro metabolites of JWH-015, an aminoalkylindole agonist for the peripheral cannabinoid receptor (CB₂) by HPLC-MS/MS Anal. Bioanal. Chem. 386(5),1345-1355(2006).
5. Sobolevsky, T., Prasolov, I., and Rodchenkov, G. Detection of JWH-018 metabolites in smoking mixture post-administration urine Forensic Sci. Int. 200(1-3),141-147(2010).