JWH 203 N-(5-hydroxypentyl) metabolite

CAS NO.：1843184-37-1
Empirical Formula: C21H22ClNO2
Molecular Weight: 355.86
Update Date: 2023-04-10 09:29:42

What is JWH 203 N-(5-hydroxypentyl) metabolite?

Description

JWH 203 is an analgesic chemical from the phenylacetylindole family that acts as a cannabinoid (CB) agonist with K_i values of 8.0 and 7.0 nM at the central (CB₁) and peripheral (CB₂) receptors, respectively.¹ Similar to the related 2'-methoxy compound JWH 250 , JWH 203 has a phenylacetyl group in place of the naphthoyl ring used in most aminoalkylindole CB compounds. Compared to JWH 250, JWH 203 displays slightly more potent binding affinities for the CB₁ and CB₂ CB receptors (JWH 250 K_is = 11 and 33 nM, respectively).¹ JWH 203 N-(5-hydroxypentyl) metabolite is expected to be a metabolite of JWH 203 that would be detectable both in serum and in urine.

References

1. Huffman, J.W., Szklennik, P.V., Almond, A., et al. 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles Bioorg. Med. Chem. Lett. 15(18),4110-4113(2005).

Properties of JWH 203 N-(5-hydroxypentyl) metabolite

Boiling point:	548.6±40.0 °C(Predicted)
Density	1.18±0.1 g/cm3(Predicted)
solubility	DMF: 10 mg/ml; DMSO: 5 mg/ml
pka	15.17±0.10(Predicted)

Safety information for JWH 203 N-(5-hydroxypentyl) metabolite

Computed Descriptors for JWH 203 N-(5-hydroxypentyl) metabolite

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