JWH 203 N-(5-hydroxypentyl) metabolite

CAS NO.：1843184-37-1
Empirical Formula: C21H22ClNO2
Molecular Weight: 355.86
Update Date: 2023-04-10 09:29:42

What is JWH 203 N-(5-hydroxypentyl) metabolite?

Description

JWH 203 is an analgesic chemical from the phenylacetylindole family that acts as a cannabinoid (CB) agonist with K_i values of 8.0 and 7.0 nM at the central (CB₁) and peripheral (CB₂) receptors, respectively.¹ Similar to the related 2'-methoxy compound JWH 250 , JWH 203 has a phenylacetyl group in place of the naphthoyl ring used in most aminoalkylindole CB compounds. Compared to JWH 250, JWH 203 displays slightly more potent binding affinities for the CB₁ and CB₂ CB receptors (JWH 250 K_is = 11 and 33 nM, respectively).¹ JWH 203 N-(5-hydroxypentyl) metabolite is expected to be a metabolite of JWH 203 that would be detectable both in serum and in urine.

References

1. Huffman, J.W., Szklennik, P.V., Almond, A., et al. 1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles Bioorg. Med. Chem. Lett. 15(18),4110-4113(2005).

Properties of JWH 203 N-(5-hydroxypentyl) metabolite

Boiling point:	548.6±40.0 °C(Predicted)
Density	1.18±0.1 g/cm3(Predicted)
solubility	DMF: 10 mg/ml; DMSO: 5 mg/ml
pka	15.17±0.10(Predicted)

Safety information for JWH 203 N-(5-hydroxypentyl) metabolite

Computed Descriptors for JWH 203 N-(5-hydroxypentyl) metabolite

New Products

N-Carbethoxy-4-piperidone 1-Aminocyclopentane carbonitrile Tetrabutylammonium perchlorate N,O-Dimethylhydroxylamine hydrochloride (RS)-beta-Amino-beta-(4-bromophenyl)propionic acid 2-Amino-5-bromo-4-(trifluoromethyl)pyridine N-Vinylformamide 4 pentyn 1 ol Phenethyl cinnamate Pyrrolo[1,2-a]pyrimidine-6-carboxylic acid, 4,6,7,8-tetrahydro-4-oxo-, sodium salt (1:1), (6S) Ethyl 3-phenylpropanoate β-Bromostyrene Methacrylate-PEG-Methacrylate, Mn:35000 2,4-Dihydroxyacetophenone 2-Chloro 5-Fluoro Pyridine Vasicinone 2-Chloroisonicotinic Acid Tween 80 or Polysorbate 80 5-Bromo-1-Pentyne 1-(2-Methyl-5-nitrophenyl)guanidine Nitrate Methyl trans-4-Aminocyclohexanecarboxylate Hydrochloride 2-Pentyn-1-oL 4-Nitrobenzotrifluoride N-(4-Cyano-3-(trifluoromethyl)phenyl)-2-methyloxirane-2-carboxamide