JWH 200 2'-naphthyl isomer

CAS NO.：133438-66-1
Empirical Formula: C25H24N2O2
Molecular Weight: 384.47
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is JWH 200 2'-naphthyl isomer?

Description

JWH 200 is a 3-indolyl-1-naphthylmethane that acts as a cannabinoid (CB) receptor agonist, binding to the CB₁ receptor with high affinity (IC₅₀ = 42 nM).¹ This synthetic cannabinoid has been identified as an adulterant of herbal blends.² JWH 200 2’-naphthyl isomer differs structurally from JWH 200 by having the naphthyl group attached at the 2’ position. The biological and toxicological properties of this compound have not been characterized. This product is intended for forensic purposes.

References

1. Huffman, J.W., Mabon, R., Wu, M.J., et al. 3-indolyl-1-naphthylmethanes: New cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB₁ cannabinoid receptor Bioorgan. Med. Chem. 11(4),539-549(2003).
2. Kikura-Hanajiri, R., Uchiyama, N., and Goda, Y. Survey of current trends in the abuse of psychotropic substances and plants in Japan Leg. Med. (Tokyo) 13(3),109-115(2011).

Properties of JWH 200 2'-naphthyl isomer

solubility	DMF: 0.30 mg/ml; DMSO: 0.15 mg/ml
form	A crystalline solid

Safety information for JWH 200 2'-naphthyl isomer

Computed Descriptors for JWH 200 2'-naphthyl isomer

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