JWH 019 N-(6-hydroxyhexyl) β-D-Glucuronide

Description

JWH 019 is a cannabimimetic indole that shows a high-affinity for both the central cannabinoid (CB₁) (K_i = 9.8 nM) and the peripheral cannabinoid (CB₂) (K_i = 5.6 nM) receptors.¹ JWH 019 N-(6-hydroxyhexyl) β-D-Glucuronide is an expected major urinary metabolite of JWH 019, based on the metabolism of similar cannabimimetics.^2,3,4 The physiological and toxicological properties of this compound have not been tested. This product is intended for forensic and research applications.

References

1. Aung, M.M., Griffin, G., Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB₁ and CB₂ receptor binding Drug Alcohol Depend. 60(2),133-140(2000).
2. Sobolevsky, T., Prasolov, I., and Rodchenkov, G. Detection of JWH-018 metabolites in smoking mixture post-administration urine Forensic Sci. Int. 200(1-3),141-147(2010).
3. Wintermeyer, A., M?ller, I., Thevis, M., et al. In vitro phase I metabolism of the synthetic cannabimimetic JWH-018 Anal. Bioanal. Chem. 398(5),2141-2153(2010).
4. Chimalakonda, K.C., Moran, C.L., Kennedy, P.D., et al. Solid-phase extraction and quantitative measurement of omega and omega-1 metabolites of JWH-018 and JWH-073 in human urine Anal. Chem. 83(16),6381-6388(2011).