JTE-013

CAS NO.：383150-41-2
Empirical Formula: C17H19Cl2N7O
Molecular Weight: 408.29
MDL number: MFCD09878275
SAFETY DATA SHEET (SDS)
Update Date: 2026-07-14 16:49:18

What is JTE-013?

Description

Sphingosine-1-phosphate (S1P) is a bioactive lipid that exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. It exerts its activity by binding to five distinct G protein-coupled receptors, S1P₁/EDG-1, S1P₂/EDG-5, S1P₃/EDG-3, S1P₄/EDG-6, and S1P₅/EDG-8. JTE-013 is a potent, selective sphingosine-1-phosphate 2 (S1P₂) receptor antagonist that binds to the human and rat receptors with IC₅₀ values of 17 and 22 nM, respectively, (IC₅₀ values >10 μM for human S1P₁ and S1P₃). It reverses the inhibitory effects of S1P on cell migration of vascular endothelial cells and smooth muscle cells. Similarly, JTE-013 reverses the inhibition of S1P on invasion and migration of B16 melanoma cells. JTE-013 inhibits S1P-induced contraction of, as well as cyclic AMP accumulation in, coronary artery smooth muscle cells.

The Uses of JTE-013

JTE-013 has been used in in vitro blood?brain barrier (BBB) and blood?tumor barrier (BTB) assays.

What are the applications of Application

JTE 013 is an EDG-5 receptor antagonist

Definition

ChEBI: 1-(2,6-dichloro-4-pyridinyl)-3-[(1,3-dimethyl-4-propan-2-yl-6-pyrazolo[3,4-b]pyridinyl)amino]urea is a pyrazolopyridine.

Biochem/physiol Actions

JTE-013 can enhance the excitability of small-diameter sensory neurons. It has the ability to repress sphingosine 1-phosphate (S1P)-mediated cellular migration.

Storage

Store at +4°C

Properties of JTE-013

Density	1.50±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: ≥20mg/mL
pka	9.32±0.43(Predicted)
form	powder
color	white to off-white

Safety information for JTE-013

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral
Precautionary Statement Codes	P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Computed Descriptors for JTE-013

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