JKE-1716
- CAS NO.：2421118-05-8
- Empirical Formula: C20H20Cl2N4O4
- Molecular Weight: 451.3
- MDL number: MFCD34474031
- Update Date: 2025-04-17 18:22:24
What is JKE-1716?
Biological Activity
JKE-1716 is an inhibitor of glutathione peroxidase 4 (GPX4) and a derivative of the GPX4 inhibitor ML-210 .1 JKE-1716 reduces viability of LOX-IMVI cancer cells in a concentration-dependent manner and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 .
References
1.Eaton, J.K., Furst, L., Ruberto, R.A., et al.Selective covalent targeting of GPX4 using masked nitrile-oxide electrophilesNat. Chem. Biol.16(5)497-506(2020)
Properties of JKE-1716
| Boiling point: | 641.1±65.0 °C(Predicted) |
| Density | 1.43±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: soluble |
| form | A crystalline solid |
| pka | 7.23±0.11(Predicted) |
| color | Off-white to light yellow |
Safety information for JKE-1716
Computed Descriptors for JKE-1716
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