JKE-1674
- CAS NO.：2421119-60-8
- Empirical Formula: C20H20Cl2N4O4
- Molecular Weight: 451.3
- MDL number: MFCD34567701
- Update Date: 2026-04-17 13:05:51
What is JKE-1674?
Biological Activity
JKE-1674 is an inhibitor of glutathione peroxidase 4 (GPX4) and an active metabolite of the GPX4 inhibitor ML-210 .1 JKE-1674 reduces viability of LOX-IMVI cancer cells (EC50 = 0.03 μM) and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 .
References
1.Eaton, J.K., Furst, L., Ruberto, R.A., et al.Selective covalent targeting of GPX4 using masked nitrile-oxide electrophilesNat. Chem. Biol.16(5)497-506(2020)
Properties of JKE-1674
| Boiling point: | 595.5±60.0 °C(Predicted) |
| Density | 1.43±0.1 g/cm3(Predicted) |
| storage temp. | 4°C, protect from light |
| solubility | DMSO: soluble |
| form | A crystalline solid |
| pka | 6.67±0.58(Predicted) |
| color | Off-white to light yellow |
Safety information for JKE-1674
Computed Descriptors for JKE-1674
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