JJH260
- CAS NO.：1831135-30-8
- Empirical Formula: C29H34ClN5O5
- Molecular Weight: 568.06
- Update Date: 2025-08-21 22:16:43
What is JJH260?
Description
JJH260 is an N-hydroxy hydantoin carbamate that inhibits androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). It blocks the hydrolysis of 9-PAHSA with an IC50 value of 0.57 μM.1 JJH260 also inhibits the novel FAHFA hydrolase androgen-dependent TFPI-regulating protein (ADTRP; IC50 = 8.5 μM), as well as the serine hydrolase ABHD6 and the lysophospholipases LYPLA1 and LYPLA2.1 JJH260 inhibits the FAHFA hydrolase activity of LNCaP and T cell lysates and intact cells.1
References
1. Parsons, W.H., Kolar, M.J., Kamat, S.S., et al. AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs Nat. Chem. Biol. 12(5),367-372(2016).
Properties of JJH260
| Boiling point: | 703.9±70.0 °C(Predicted) |
| Density | 1.39±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 1 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml |
| form | A crystalline solid |
| pka | 3.53±0.12(Predicted) |
| color | Off-white to light yellow |
Safety information for JJH260
Computed Descriptors for JJH260
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