JJH260

CAS NO.：1831135-30-8
Empirical Formula: C29H34ClN5O5
Molecular Weight: 568.06
Update Date: 2025-08-21 22:16:43

What is JJH260?

Description

JJH260 is an N-hydroxy hydantoin carbamate that inhibits androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). It blocks the hydrolysis of 9-PAHSA with an IC₅₀ value of 0.57 μM.¹ JJH260 also inhibits the novel FAHFA hydrolase androgen-dependent TFPI-regulating protein (ADTRP; IC₅₀ = 8.5 μM), as well as the serine hydrolase ABHD6 and the lysophospholipases LYPLA₁ and LYPLA₂.¹ JJH260 inhibits the FAHFA hydrolase activity of LNCaP and T cell lysates and intact cells.¹

References

1. Parsons, W.H., Kolar, M.J., Kamat, S.S., et al. AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs Nat. Chem. Biol. 12(5),367-372(2016).

Properties of JJH260

Boiling point:	703.9±70.0 °C(Predicted)
Density	1.39±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 1 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml
form	A crystalline solid
pka	3.53±0.12(Predicted)
color	Off-white to light yellow

Safety information for JJH260

Computed Descriptors for JJH260

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