JH-II-127

Synonym(s):[4-[[5-Chloro-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxyphenyl]-4-morpholinylmethanone

CAS NO.：1700693-08-8
Empirical Formula: C19H21ClN6O3
Molecular Weight: 416.86
MDL number: MFCD28975160
Update Date: 2026-07-17 09:03:53

What is JH-II-127?

Description

JH-II-127 is an orally bioavailable inhibitor of wild-type (WT) and mutant forms of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, as well as LRRK2 containing the G2019S and A2016T substitution mutations (IC₅₀s = 6.6, 2.2, and 47.7 nM, respectively), which are present in certain patients with Parkinson’s disease, but not LRRK2 containing both mutations (IC₅₀ = 3,080 nM). JH-II-127 (0.1-0.3 μM) inhibits phosphorylation of the serines at positions 910 and 935 of WT LRRK2 and LRRK2^G2019S in vitro. It also inhibits Ser935 phosphorylation in vivo in mouse brain, spleen, and kidney when administered at a dose of 30 mg/kg.

The Uses of JH-II-127

JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor.

Storage

Store at -20°C

Properties of JH-II-127

Melting point:	>166°C (dec.)
Density	1.458±0.06 g/cm3(Predicted)
storage temp.	Refrigerator
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	12.49±0.50(Predicted)
color	White to Pale Beige

Safety information for JH-II-127

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for JH-II-127

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