JAK3 covalent inhibitor-1
- CAS NO.：2300106-50-5
- Empirical Formula: C22H17FN6O2S
- Molecular Weight: 448.47
- MDL number: MFCD32067927
- Update Date: 2026-04-24 14:58:25
What is JAK3 covalent inhibitor-1?
Description
JAK3 covalent inhibitor-1 is a potent and selective janus kinase 3 (JAK3) covalent inhibitor with an IC50 of 11 nM and shows 246-fold selectivity vs other JAKs[1]. JAK3|11 nM (IC50)
References
[1]. Casimiro-Garcia A, et al. Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors. J Med Chem. 2018 Dec 13;61(23):10665-10699.
Properties of JAK3 covalent inhibitor-1
| Density | 1.55±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 9.70±0.40(Predicted) |
Safety information for JAK3 covalent inhibitor-1
Computed Descriptors for JAK3 covalent inhibitor-1
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