JAK-IN-3

CAS NO.：1400876-94-9
Empirical Formula: C18H20N4O3
Molecular Weight: 340.38
MDL number: MFCD31813914
Update Date: 2026-07-27 17:00:41

What is JAK-IN-3?

Biological Activity

JAK-IN-3 (compound 22) is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively[1].

References

[1]. Spergel SH, et al. Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis. ACS Med Chem Lett. 2019 Feb 13;10(3):306-311.

Properties of JAK-IN-3

Density	1.39±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
pka	12.70±0.50(Predicted)
form	Solid
color	Light brown to brown

Safety information for JAK-IN-3

Computed Descriptors for JAK-IN-3

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