JAK-IN-3
- CAS NO.：1400876-94-9
- Empirical Formula: C18H20N4O3
- Molecular Weight: 340.38
- MDL number: MFCD31813914
- Update Date: 2026-07-27 17:00:41
What is JAK-IN-3?
Biological Activity
JAK-IN-3 (compound 22) is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively[1].
References
[1]. Spergel SH, et al. Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis. ACS Med Chem Lett. 2019 Feb 13;10(3):306-311.
Properties of JAK-IN-3
| Density | 1.39±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| pka | 12.70±0.50(Predicted) |
| form | Solid |
| color | Light brown to brown |
Safety information for JAK-IN-3
Computed Descriptors for JAK-IN-3
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