jaconine

CAS NO.：480-75-1
Empirical Formula: C18H25NO8
Molecular Weight: 387.86
MDL number: MFCD01684238
SAFETY DATA SHEET (SDS)
Update Date: 2025-04-17 18:22:24

What is jaconine?

Description

This alkaloid from Senecio Jacobea was originally given the empirical formula ClsH2S0sN by Barger and Blackie but has since been shown to exist as the chlorine-containing compound. It has[α] _D + 52.5° (CHCl3 ) and on hydrolysis yields retronecine and jaconecic acid, ClOH160 6, m.p. l83-4°C; [α]²⁵_D + 28.1 ° (EtOH). In this reaction, the chlorine is also lost by hydrolysis. The base forms a dihydrochloride, m.p. 204-5°C (dec.).

References

Manske., Can. J. Res., S, 651 (1931)
Barger, Blackie.,J. Chern. Soc., 584 (1937)
Adana et al., J. Arner. Chern. Soc., 78,3513 (1956)
Bradbury, Willis., Austral. J. Chern., 9,258 (1956)
Geissman., ibid, 12,247 (1959)

Properties of jaconine

Melting point:	146 °C
Boiling point:	180 °C
Density	1.36±0.1 g/cm3(Predicted)
pka	11.66±0.60(Predicted)

Safety information for jaconine

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P262:Do not get in eyes, on skin, or on clothing. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for jaconine

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