Isopimaric acid

CAS NO.：5835-26-7
Empirical Formula: C20H30O2
Molecular Weight: 302.45
MDL number: MFCD04113116
EINECS: 200-258-5
SAFETY DATA SHEET (SDS)
Update Date: 2026-09-12 18:49:17

What is Isopimaric acid?

Description

Isopimaric acid (5835-26-7) is a terpenoid acid that activates BK (voltage-gated potassium) channels when used at 10 μM in HEK293 cells.1 Improves spatial and non-spatial memory in Alzheimer’s mouse model2,3, and significantly improves motor function in a rat spinal cord injury model4. Reduces hyperactivity of spontaneously active auditory networks, EC50=7.8 μM.5

The Uses of Isopimaric acid

A potent novel activators of large-conductance Ca2+-activated K+ channel.

What are the applications of Application

Isopimaric Acid is potent Ca-activated K+ channel opener

Definition

ChEBI: Isopimaric acid is a diterpenoid, a carbotricyclic compound and a monocarboxylic acid. It is a conjugate acid of an isopimarate. It derives from a hydride of an isopimara-7,15-diene.

General Description

Isopimaric acid, a resin acid produced by conifer trees, is a tricyclic diterpene compound. High levels of isopimaric acid in the hepatocytes of the rainbow trout may impair calcium signalling machinery. Isopimaric acid is a potential big potassium (BK) channel opener.

Biochem/physiol Actions

Potent opener of large conductance calcium activated K+ (BK) channels.

References

Imaizumi et al. (2002), Molecular basis of pimarane compounds as novel activators of large-conductance CA(2+)-activated K(+) channel alpha-subunit; Mol. Pharmacol., 62 836 Wang et al. (2015), Cognitive recovery by chronic activation of the large-conductance calcium-activated potassium channel in a mouse model of Alzheimer’s disease; Neuropharmacology, 92 8 Wang et al. (2015), Improvement of spatial learning by facilitating large-conductance calcium-activated potassium channel with transcranial magnetic stimulation in Alzheimer’s disease model mice; Neuropharmacology, 97 210 Jacobsen et al. (2018), Activation of the Large-conductance, Voltage, and Ca2+-Activated K+ (BK) Channel in Acute Spinal Cord Injury in the Wistar Rat is Neuroprotective; Front. Neurol., 9 1107 Wu et al. (2014), Pharmacodynamics of potassium channel openers in cultured neuronal networks; Eur. J. Pharmacol., 732 68

Properties of Isopimaric acid

Melting point:	160°
Boiling point:	383.47°C (rough estimate)
alpha	D16 -3.6° (10.4% soln in 1:1 alcohol:chloroform)
Density	1.0434 (rough estimate)
refractive index	1.4980 (estimate)
storage temp.	-20°C
solubility	DMSO: ~26 mg/mL
form	solid
pka	4?+-.0.60(Predicted)
color	white
Stability:	Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
EPA Substance Registry System	Isopimaric acid (5835-26-7)

Safety information for Isopimaric acid

Signal word	Warning
Pictogram(s)	Environment GHS09
GHS Hazard Statements	H400:Hazardous to the aquatic environment, acute hazard
Precautionary Statement Codes	P273:Avoid release to the environment.