Isazophos

Description

Isazofos is a yellow liquid. Solubility in water is 168 mg/L (20 ?C). It is miscible with common organic solvents. Log Kow = 2.99. It is hydrolyzed in aqueous media: DT₅₀ values (20 ?C) at pH 5, 7, and 9 are 85, 48, and 19 d, respectively.

The Uses of Isazophos

Isazophos is an organophosphate pesticide.

The Uses of Isazophos

Nematocide; turf insecticide.

The Uses of Isazophos

Isazofos is used as a nematicide and soil insecticide in bananas, citrus, cotton, beet, maize, rice, vegetables, sugar cane and turf.

Definition

ChEBI: Isazofos is an organic thiophosphate.

Metabolic pathway

Isazofos is metabolised in soil to its hydrolysis product 5-chloro-1- isopropyl-3-triazolol. The oxon metabolite has apparently not been identified.

Metabolism

In mammals, administered isazofos is rapidly metabolized and excreted, primarily in the urine, without accumulation in the body. The degradation route of isazofos in soil is primarily the hydrolysis mediated by microorganisms to give 5-chloro-1-isopropyl-3-triazole. The half-life in soils is about 10 d.

Degradation

Isazofos is hydrolysed more rapidly in alkaline rather than acid solution. The DT₅₀ values at pH 5, 7 and 9 were 85, 48 and 19 days, respectively (PM).

Toxicity evaluation

Acute oral LD₅₀ for rats is 40–60 mg/kg. Inhalation LC50 (4 h) for rats is about 0.24 mg/L air. NOEL (90 d) for rats is 2 mg/kg diet (0.1 mg/kg/d).