Isazophos
- CAS NO.：42509-80-8
- Empirical Formula: C9H17ClN3O3PS
- Molecular Weight: 313.74
- MDL number: MFCD00078699
- EINECS: 255-863-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:25:34
What is Isazophos?
Description
Isazofos is a yellow liquid. Solubility in water is 168 mg/L (20 ?C). It is miscible with common organic solvents. Log Kow = 2.99. It is hydrolyzed in aqueous media: DT50 values (20 ?C) at pH 5, 7, and 9 are 85, 48, and 19 d, respectively.
The Uses of Isazophos
Isazophos is an organophosphate pesticide.
The Uses of Isazophos
Nematocide; turf insecticide.
The Uses of Isazophos
Isazofos is used as a nematicide and soil insecticide in bananas, citrus, cotton, beet, maize, rice, vegetables, sugar cane and turf.
Definition
ChEBI: Isazofos is an organic thiophosphate.
Metabolic pathway
Isazofos is metabolised in soil to its hydrolysis product 5-chloro-1- isopropyl-3-triazolol. The oxon metabolite has apparently not been identified.
Metabolism
In mammals, administered isazofos is rapidly metabolized and excreted, primarily in the urine, without accumulation in the body. The degradation route of isazofos in soil is primarily the hydrolysis mediated by microorganisms to give 5-chloro-1-isopropyl-3-triazole. The half-life in soils is about 10 d.
Degradation
Isazofos is hydrolysed more rapidly in alkaline rather than acid solution. The DT50 values at pH 5, 7 and 9 were 85, 48 and 19 days, respectively (PM).
Toxicity evaluation
Acute oral LD50 for rats is 40–60 mg/kg. Inhalation LC50 (4 h) for rats is about 0.24 mg/L air. NOEL (90 d) for rats is 2 mg/kg diet (0.1 mg/kg/d).
Properties of Isazophos
| Melting point: | <25℃ |
| Boiling point: | bp0.001 100°; bp760 170° |
| Density | 1.22 g/cm3 (20℃) |
| vapor pressure | 7.45 x 10-3 Pa (20 °C) |
| refractive index | nD20 1.4867 |
| storage temp. | 0-6°C |
| form | liquid |
| Water Solubility | 168 mg l-1 (20 °C) |
| pka | -1.47±0.10(Predicted) |
| BRN | 8145294 |
| EPA Substance Registry System | Isazofos (42509-80-8) |
Safety information for Isazophos
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08  Environment GHS09 |
| GHS Hazard Statements |
H317:Sensitisation, Skin H373:Specific target organ toxicity, repeated exposure H410:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P262:Do not get in eyes, on skin, or on clothing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P314:Get medical advice/attention if you feel unwell. |
Computed Descriptors for Isazophos
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