Irsogladine maleate
- CAS NO.：84504-69-8
- Empirical Formula: C13H11Cl2N5O4
- Molecular Weight: 372.16
- MDL number: MFCD00873566
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-01-13 11:25:22
What is Irsogladine maleate?
Description
Irsogladine is a gastroprotective agent. It increases transfer of Lucifer yellow CH between isolated rabbit gastric epithelial cells, indicating enhanced gap junction intercellular communication (GJIC). Irsogladine (3 mg/kg) inhibits gastric mucosal lesion formation and decreases in gastric mucosal blood flow induced by monochloramine in rats, effects that can be prevented by the nitric oxide synthase inhibitor L-NAME . It also inhibits superoxide anion production induced by fMLP and increases cAMP levels in isolated human neutrophils in a concentration-dependent manner, similar to the phosphodiesterase 4 (PDE4) inhibitor rolipram .
Chemical properties
White Solid
The Uses of Irsogladine maleate
An anti-ulcer drug.
The Uses of Irsogladine maleate
antiulcerative;selective PDE4 inhibitor which also enhances gap junction intercellular communication
The Uses of Irsogladine maleate
An anti-ulcer drug. Potent PDE4 inhibitor
What are the applications of Application
Irsogladine maleate is a PDE4 inhibitor and muscarinic acetylcholine receptor binder
Definition
ChEBI: Irsogladine maleate is a dichlorobenzene.
Biological Activity
Phosphodiesterase 4 (PDE4) inhibitor that displays gastroprotective properties. Prevents gastric mucosal injury induced by monochloramine and ischemia-reperfusion. Activates gap-junctional intercellular communication improving gastric mucosal barrier function. Inhibits superoxide production in human neutrophils and inhibits in vitro and in vivo angiogenesis.
Properties of Irsogladine maleate
| Melting point: | 181-182°C |
| storage temp. | Inert atmosphere,Room Temperature |
| Water Solubility | Insoluble in water |
| solubility | DMF:30.0(Max Conc. mg/mL);80.61(Max Conc. mM) DMSO:30.0(Max Conc. mg/mL);80.61(Max Conc. mM) DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.67(Max Conc. mM) |
| form | White crystalline powder. |
| color | White to Almost white |
| Merck | 14,5102 |
| CAS DataBase Reference | 84504-69-8(CAS DataBase Reference) |
Safety information for Irsogladine maleate
Computed Descriptors for Irsogladine maleate
New Products
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