iproniazid

Originator

Marsilid,Roche,US,1952

The Uses of iproniazid

Iproniazid is a hydrazine based drug used as an antidepressant. Iproniazid acts as an irreversible and nonselective monoamine oxidase inhibitor.

What are the applications of Application

Iproniazid is an inhibitor of MAO

Definition

ChEBI: Iproniazid is a carbohydrazide and a member of pyridines.

Manufacturing Process

A mixture of 40 g of isonicotinyl hydrazine and 600 cc of acetone was heated on a steam bath until solution was complete. Upon cooling the reaction mixture, 1-isonicotinyl-2-isopropylidene hydrazine precipitated in the form of white needles; MP 161°C to 161.5°C.
A solution of 20 g of 1-isonicotinyl-2-isopropylidene hydrazine in 150 cc of methanol was reduced with hydrogen at room temperature and 50 psi using 300 mg of platinum black as a catalyst.

brand name

Euphozid;Ipropran;Isotamine;Laniazid;Marsilid;Nydrazid;P-1-n forte;Pms isoniazid;Rifamate;Rimactane;Rimifon;Ro 7-1554;Teebaconin;Triniad;Uniad.

Therapeutic Function

Antidepressant, Monoamine oxidase inhibitor

World Health Organization (WHO)

Iproniazid, a monoamine oxidase inhibitor (MAOI), was introduced in 1952 for the treatment of depressive illness. Subsequently concern regarding potentially serious interactions between MAOIs and foods containing tyramine inspired much restrictive regulatory action. However, MAOIs still retain a place in the treatment of serious depressive illness although there is no international consensus on which compounds should be preferred. Thus iproniazid remains available in several countries.

Purification Methods

Crystallise it from *benzene or *benzene /pet ether and dry it in a vacuum. It is soluble in H2O and EtOH. [Fox & Gibas J Org Chem 18 994 1953.] The dihydrochloride has m 227-228o (from EtOH). [Beilstein 22 III/IV 551.] It is an antidepressant.