INT-767
- CAS NO.：1000403-03-1
- Empirical Formula: C25H45NaO6S
- Molecular Weight: 496.68
- Update Date: 2026-09-15 17:54:07
What is INT-767?
Description
INT-767 is a G-protein coupled/Farnesoid X-activated receptor agonist potentially for the treatment of hepatic fibrosis. INT-767 significantly improved serum liver enzymes, hepatic inflammation, and biliary fibrosis in Mdr2(-/-) mice. INT-767 significantly induced bile flow and biliary HCO?3- output, as well as gene expression of carbonic anhydrase 14, an important enzyme able to enhance HCO?3- transport, in an Fxr-dependent manner. In addition, INT-767 dramatically reduced bile acid synthesis via the induction of ileal Fgf15 and hepatic Shp gene expression, thus resulting in significantly reduced biliary bile acid output in Mdr2(-/-) mice.
Properties of INT-767
| storage temp. | Store at -20°C |
| solubility | DMSO : ≥ 205.5 mg/mL (415.44 mM) |
| form | Solid |
| color | White to off-white |
Safety information for INT-767
Computed Descriptors for INT-767
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