INDORAMIN

The Uses of INDORAMIN

Antihypertensive.

Clinical Use

Alpha-adrenoceptor blocker:

Hypertension

Benign prostatic hyperplasia (BPH)

Drug interactions

Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Analgesics: antagonism of hypotensive effect with NSAIDs.
Avanafil, vardenafil, sildenafil and tadalafil: enhanced hypotensive effect - avoid.
Antidepressants: enhanced hypotensive effect, especially with MAOIs and linezolid - avoid.
Beta-blockers: enhanced hypotensive effect; increased risk of first dose hypotensive effect.
Calcium-channel blockers: enhanced hypotensive effect; increased risk of first dose hypotensive effect.
Diuretics: enhanced hypotensive effect; increased risk of first dose hypotensive effect.
Moxisylyte: possibly severe postural hypotension when used in combination.

Metabolism

In studies with radiolabelled indoramin at doses of 40-60 mg daily for up to three days, after two or three days 35% of the radioactivity was excreted in the urine and 46% in the faeces. Extensive first pass metabolism was suggested. There is evidence to suggest that some metabolites may have some alpha-adrenoceptor blocking activity.