Indole-6-carboxylic acid

Synonym(s):6-Carboxyindole

CAS NO.：1670-82-2
Empirical Formula: C9H7NO2
Molecular Weight: 161.16
MDL number: MFCD02258929
EINECS: 605-464-3
SAFETY DATA SHEET (SDS)
Update Date: 2026-05-28 05:54:59

What is Indole-6-carboxylic acid?

Chemical properties

yellow-beige to orange-brown powder

The Uses of Indole-6-carboxylic acid

• ;Reactant for preparation of D-glutamic acid-based inhibitors of E. coli MurD ligase1• ;Reactant for preparation of indolylindazoles and indolylpyrazolopyridines as interleukin-2 inducible T cell kinase inhibitors2• ;Reactant for preparation of amide conjugates with ketoprofen, as inhibitors of Gli1-mediated transcription in Hedgehog pathway3• ;Reactant for preparation of piperazine-bisamide analogs as human growth hormone secretagogue receptor antagonists for treatment of obesity4• ;Reactant for preparation of pyridinyl carboxylates via esterification with chlorohyd

The Uses of Indole-6-carboxylic acid

Reactant for preparation of D-glutamic acid-based inhibitors of E. coli MurD ligase ? Reactant for preparation of indolylindazoles and indolylpyrazolopyridines as interleukin-2 inducible T cell kinase inhibitors ? Reactant for preparation of amide conju

The Uses of Indole-6-carboxylic acid

Reactant for preparation of D-glutamic acid-based inhibitors of E. coli MurD ligase
Reactant for preparation of indolylindazoles and indolylpyrazolopyridines as interleukin-2 inducible T cell kinase inhibitors
Reactant for preparation of amide conjugates with ketoprofen, as inhibitors of Gli1-mediated transcription in Hedgehog pathway
Reactant for preparation of piperazine-bisamide analogs as human growth hormone secretagogue receptor antagonists for treatment of obesity
Reactant for preparation of pyridinyl carboxylates via esterification with chlorohydroxypyridine as SARS-CoV 3CL proinhibitors
Reactant for preparation of (indolecarbonyl)-D-phenylglycinamide amides as factor Xa inhibitors

Synthesis Reference(s)

Journal of Medicinal Chemistry, 35, p. 2419, 1992 DOI: 10.1021/jm00091a010

Properties of Indole-6-carboxylic acid

Melting point:	249-253 °C(lit.)
Boiling point:	287.44°C (rough estimate)
Density	1.2480 (rough estimate)
refractive index	1.5050 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	4.44±0.30(Predicted)
form	Powder
color	Yellow-beige to orange-brown
BRN	123991
CAS DataBase Reference	1670-82-2(CAS DataBase Reference)

Safety information for Indole-6-carboxylic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.