Indobufen

CAS NO.：63610-08-2
Empirical Formula: C18H17NO3
Molecular Weight: 295.34
MDL number: MFCD00572250
EINECS: 264-364-4
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-21 17:10:26

What is Indobufen?

Description

Indobufen is a platelet aggregation inhibitor related to the antiinflammatory agent indoprofen. It has shown clinical efficacy in peripheral artery disease, in prevention of deep vein thrombosis after myocardial infarction, and in blocking excercise-induced increase in platelet aggregation in angina patients.

Originator

Erbamont (Italy)

The Uses of Indobufen

Indobufen is a platelet aggregation inhibitor. Indobufen is the anticoagulant drug and platelet aggregation inhibitor, which has anti-inflammatory analgesic effect. Indobufen is used as an antithrombotic.

What are the applications of Application

Indobufen is a platelet aggregation inhibitor and reversible cyclooxygenase inhibitor

Definition

ChEBI: Indobufen is a member of isoindoles.

brand name

IBUSTRIN

Clinical Use

A reversible but very potent inhibitor of platelet COX-1 activity, was shown to have comparable clinical efficacy to that of aspirin in prevention of DVT after myocardial infarction and in blocking exercise-induced increase in platelet aggregation. In the secondary prevention of thromboembolic events, 100 or 200 mg of indobufen twice daily is as effective as warfarin or aspirin in patients with or without atrial fibrillation. Currently, indobufen is only available for routine clinical use in Europe.

Properties of Indobufen

Melting point:	182-184°
Boiling point:	518.1±50.0 °C(Predicted)
Density	1.275±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	4.39±0.10(Predicted)
color	White
InChI	InChI=1S/C18H17NO3/c1-2-15(18(21)22)12-7-9-14(10-8-12)19-11-13-5-3-4-6-16(13)17(19)20/h3-10,15H,2,11H2,1H3,(H,21,22)
CAS DataBase Reference	63610-08-2(CAS DataBase Reference)
EPA Substance Registry System	Benzeneacetic acid, 4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-.alpha.-ethyl- (63610-08-2)

Safety information for Indobufen

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.