Indinavir sulfate

CAS NO.：157810-81-6
Empirical Formula: C36H49N5O8S
Molecular Weight: 711.87
MDL number: MFCD00920346
EINECS: 682-418-9
SAFETY DATA SHEET (SDS)
Update Date: 2026-01-20 19:14:41

What is Indinavir sulfate?

Description

Indinavir is an HIV-1 protease inhibitor (K_i = 0.358 nM). It is selective for HIV-1 protease over HIV-2 protease (K_i = 3.316 nM), as well as human cathepsin D, porcine pepsin, bovine chymosin, human plasma renin, Factor Xa, and elastase at 10 μM. It is also selective for wild-type HIV-1 protease over the protease inhibitor-resistant mutants A-44, K-60, and V-18 (K_is = 0.24, 15, 50, and 40 nM, respectively). Indinavir is active against multiple HIV-1 variants in cell-based assays (IC₉₅s = 12-100 nM). Formulations containing indinavir have been used in combination with antiretroviral agents in the treatment of HIV infection.

Chemical properties

Crystalline Solid

The Uses of Indinavir sulfate

Indinavir Sulfate is a member of the novel hydroxyaminopentane amide class of HIV-1 protease inhibitors. Antiviral. It is a COVID19-related research product.

Definition

ChEBI: Indinavir sulfate is an azaheterocycle sulfate salt. It is functionally related to an indinavir.

What are the applications of Application

Indinavir Sulfate is a member of the hydroxyaminopentane amide class of HIV-1 protease inhibitors

brand name

Crixivan (Merck).

Hazard

Moderately toxic by ingestion.

Storage

Properties of Indinavir sulfate

Melting point:	150-153°C (dec)
storage temp.	-20°C Freezer
solubility	Freely soluble in water, soluble in methanol, practically insoluble in heptane.
form	Solid
color	White to Off-White
Water Solubility	>100g/L(temperature not stated)

Safety information for Indinavir sulfate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.