PZ703b
- CAS NO.：2471970-56-4
- Empirical Formula: C80H102ClF3N10O11S4
- Molecular Weight: 1600.44
- Update Date: 2026-04-24 14:58:09
What is PZ703b?
Description
PZ703b is a potent BCL-PROTAC. PZ703b exhibits high potency in inducing BCL-XL degradation and in inhibiting but not degrading BCL-2, showing a hybrid dual-targeting mechanism of action that is unprecedented in a PROTAC molecule. As a result, PZ703b is highly potent in killing BCL-XL dependent, BCL-2 dependent, and BCL-XL/BCL-2 dual-dependent cells in an E3 ligase (VHL)-dependent fashion.
Properties of PZ703b
| Density | 1.37±0.1 g/cm3(Predicted) |
| pka | 4.60±0.10(Predicted) |
| form | Solid |
| color | White to off-white |
Safety information for PZ703b
Computed Descriptors for PZ703b
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