Urea, N-[3,5-bis(trifluoromethyl)phenyl]-N′-[(S)-phenyl[5-[(phenylmethyl)thio]-1,3,4-oxadiazol-2-yl]methyl]-
- CAS NO.：2718170-45-5
- Empirical Formula: C25H18F6N4O2S
- Molecular Weight: 552.49
- Update Date: 2026-07-14 16:49:18
![Urea, N-[3,5-bis(trifluoromethyl)phenyl]-N′-[(S)-phenyl[5-[(phenylmethyl)thio]-1,3,4-oxadiazol-2-yl]methyl]- Structural](https://img.chemicalbook.in/CAS/20211123/GIF/2718170-45-5.gif)
What is Urea, N-[3,5-bis(trifluoromethyl)phenyl]-N′-[(S)-phenyl[5-[(phenylmethyl)thio]-1,3,4-oxadiazol-2-yl]methyl]-?
Biological Activity
RECQL5-IN-1 (Compound 4a) acts as an orally effective RECQL5 inhibitor (targeting both enzymatic and nonenzymatic domain). RECQL5-IN-1 is a potent inhibitor of RECQL5 helicase activity (IC50=46.3 nM). RECQL5-IN-1 inhibits RECQL5-WT cells and RECQL5-KO2 cells with IC50s of 4.8 μM and 19.6 μM, respectively. RECQL5-IN-1 can be used for the research of breast cancer[1].
References
[1]. Saikat Chakraborty, et al. Targeting RECQL5 Functions, by a Small Molecule, Selectively Kills Breast Cancer in Vitr o and in Vivo. J Med Chem. 2021 Feb 11;64(3):1524-1544.
Properties of Urea, N-[3,5-bis(trifluoromethyl)phenyl]-N′-[(S)-phenyl[5-[(phenylmethyl)thio]-1,3,4-oxadiazol-2-yl]methyl]-
| Density | 1.47±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| form | Solid |
| pka | 10.92±0.46(Predicted) |
| color | White to off-white |
Safety information for Urea, N-[3,5-bis(trifluoromethyl)phenyl]-N′-[(S)-phenyl[5-[(phenylmethyl)thio]-1,3,4-oxadiazol-2-yl]methyl]-
Computed Descriptors for Urea, N-[3,5-bis(trifluoromethyl)phenyl]-N′-[(S)-phenyl[5-[(phenylmethyl)thio]-1,3,4-oxadiazol-2-yl]methyl]-
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