5,8,11,14-Eicosatetraenamide, N-[(1R)-2-hydroxy-1-methylethyl]-13-methyl-, (5Z,8Z,11Z,13S,14Z)-
- CAS NO.：2244425-65-6
- Empirical Formula: C24H41NO2
- Molecular Weight: 375.59
- Update Date: 2023-03-31 09:12:58
![5,8,11,14-Eicosatetraenamide, N-[(1R)-2-hydroxy-1-methylethyl]-13-methyl-, (5Z,8Z,11Z,13S,14Z)- Structural](https://img.chemicalbook.in/CAS/20240320/GIF/2244425-65-6.gif)
What is 5,8,11,14-Eicosatetraenamide, N-[(1R)-2-hydroxy-1-methylethyl]-13-methyl-, (5Z,8Z,11Z,13S,14Z)-?
Description
AMG-315 is a Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes. AMG-315 is a chiral arachidonoyl ethanolamide (AEA) analogue or (13S,1′R)-dimethylanandamide. AMG-315 is a high affinity ligand for the CB1 receptor (Ki of 7.8 ± 1.4 nM) that behaves as a potent CB1 agonist in vitro (EC50 = 0.6 ± 0.2 nM). AMG-315 is the first potent AEA analogue with significant stability for all endocannabinoid hydrolyzing enzymes as well as the oxidative enzymes COX-2. AMG-315 will serve as a very useful endocannabinoid probe.
Properties of 5,8,11,14-Eicosatetraenamide, N-[(1R)-2-hydroxy-1-methylethyl]-13-methyl-, (5Z,8Z,11Z,13S,14Z)-
| Boiling point: | 536.0±50.0 °C(Predicted) |
| Density | 0.931±0.06 g/cm3(Predicted) |
| pka | 14.51±0.10(Predicted) |
Safety information for 5,8,11,14-Eicosatetraenamide, N-[(1R)-2-hydroxy-1-methylethyl]-13-methyl-, (5Z,8Z,11Z,13S,14Z)-
Computed Descriptors for 5,8,11,14-Eicosatetraenamide, N-[(1R)-2-hydroxy-1-methylethyl]-13-methyl-, (5Z,8Z,11Z,13S,14Z)-
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