(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH

CAS NO.：2086301-47-3
Empirical Formula: C39H58N6O7S
Molecular Weight: 754.98
Update Date: 2025-04-17 18:22:24

What is (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH?

Biological Activity

(S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH (VH032-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH) is a E3 ligase ligand-linker conjugate that contains on one end a VHL ligand. (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH is used in PROTAC technology[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].

References

[1]. Yimin Qian, et al. Compounds and methods for the targeted degradation of bromodomain-containing proteins. WO2017030814A1. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-991.

Properties of (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH

Boiling point:	935.9±65.0 °C(Predicted)
Density	1.26±0.1 g/cm3(Predicted)
solubility	DMSO : 220 mg/mL (291.40 mM; Need ultrasonic)
form	Solid
pka	12.07±0.40(Predicted)
color	White to off-white

Safety information for (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH

Computed Descriptors for (S,R,S)-AHPC-Boc-trans-3-aminocyclobutanol-Pip-CH2COOH

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