AEG 40730 dihydrochloride
- CAS NO.：1883545-50-3
- Empirical Formula: C52H69ClF6N8O8
- Molecular Weight: 1083.61
- Update Date: 2026-04-21 10:31:43
What is AEG 40730 dihydrochloride?
Description
AEG40730 is a potent and selective IAP antagonist and a BIR-binding tetrapeptide. AEG40730 binds to cIAP1 and cIAP2, facilitates their autoubiquitination and proteosomal degradation, and causes a dramatic reduction in RIP1 ubiquitination. Treatment with nanomolar concentrations of AEG40730 resulted in the loss of both XIAP and c-IAP1 proteins, albeit with different kinetics.
Safety information for AEG 40730 dihydrochloride
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