Carbamic acid, N-?[(2,?4-?difluorophenyl)?methyl]?-?, (3R)?-?3-?[7-?[[[(2,?4-?difluorophenyl)?methyl]?amino]?carbonyl]?-?1,?8-?dihydro-?9-?hydroxy-?1,?8-?dioxo-?2H-?pyrido[1,?2-?a]?pyrazin-?2-?yl]?butyl ester

CAS NO.：2244161-73-5
Empirical Formula: C28H24F4N4O6
Molecular Weight: 588.51
Update Date: 2022-12-21 16:56:50

What is Carbamic acid, N-?[(2,?4-?difluorophenyl)?methyl]?-?, (3R)?-?3-?[7-?[[[(2,?4-?difluorophenyl)?methyl]?amino]?carbonyl]?-?1,?8-?dihydro-?9-?hydroxy-?1,?8-?dioxo-?2H-?pyrido[1,?2-?a]?pyrazin-?2-?yl]?butyl ester?

The Uses of Carbamic acid, N-?[(2,?4-?difluorophenyl)?methyl]?-?, (3R)?-?3-?[7-?[[[(2,?4-?difluorophenyl)?methyl]?amino]?carbonyl]?-?1,?8-?dihydro-?9-?hydroxy-?1,?8-?dioxo-?2H-?pyrido[1,?2-?a]?pyrazin-?2-?yl]?butyl ester

Des-butanoyl 3,4-Didehydro-N-butyl(2,4-difluorobenzyl)carbamate Dolutegravir is an impurity of Dolutegravir (D528800), a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.

Properties of Carbamic acid, N-?[(2,?4-?difluorophenyl)?methyl]?-?, (3R)?-?3-?[7-?[[[(2,?4-?difluorophenyl)?methyl]?amino]?carbonyl]?-?1,?8-?dihydro-?9-?hydroxy-?1,?8-?dioxo-?2H-?pyrido[1,?2-?a]?pyrazin-?2-?yl]?butyl ester

Boiling point:	778.0±60.0 °C(Predicted)
Density	1.51±0.1 g/cm3(Predicted)
pka	4.50±1.00(Predicted)

Safety information for Carbamic acid, N-?[(2,?4-?difluorophenyl)?methyl]?-?, (3R)?-?3-?[7-?[[[(2,?4-?difluorophenyl)?methyl]?amino]?carbonyl]?-?1,?8-?dihydro-?9-?hydroxy-?1,?8-?dioxo-?2H-?pyrido[1,?2-?a]?pyrazin-?2-?yl]?butyl ester

Computed Descriptors for Carbamic acid, N-?[(2,?4-?difluorophenyl)?methyl]?-?, (3R)?-?3-?[7-?[[[(2,?4-?difluorophenyl)?methyl]?amino]?carbonyl]?-?1,?8-?dihydro-?9-?hydroxy-?1,?8-?dioxo-?2H-?pyrido[1,?2-?a]?pyrazin-?2-?yl]?butyl ester

Carbamic acid, N-?[(2,?4-?difluorophenyl)?methyl]?-?, (3R)?-?3-?[7-?[[[(2,?4-?difluorophenyl)?methyl]?amino]?carbonyl]?-?1,?8-?dihydro-?9-?hydroxy-?1,?8-?dioxo-?2H-?pyrido[1,?2-?a]?pyrazin-?2-?yl]?butyl ester manufacturer

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product: 2244161-73-5 NLT 95%

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