17(S)-HDHA-d5

CAS NO.：2738376-87-7
Empirical Formula: C22H27D5O3
Molecular Weight: 349.52
Update Date: 2025-07-27 11:21:16

What is 17(S)-HDHA-d5?

Description

17(S)-HDHA-d₅ is intended for use as an internal standard for the quantification of 17(S)-HDHA by GC- or LC-MS. (±)17-HDHA is formed via autooxidation of docosahexaenoic acid (DHA) .¹ 17(S)-HDHA is formed from DHA by 15-lipoxygenase (15-LO) and is a precursor in the formation of 17(S)-resolvin D1 .² 17(R)-HDHA is formed by aspirin-acetylated COX-2-mediated oxidation of DHA and is a precursor in the formation 17(R)-resolvin D1 .

References

1. VanRollins, M., and Murphy, R.C. Autooxidation of docosahexaenoic acid: Analysis of ten isomers of hydroxydocosahexaenoate J. Lipid Res. 25(5),507-517(1984).
2. Sun, Y.P., Oh, S.F., Uddin, J., et al. Resolvin D1 and its aspirin-triggered 17R epimer stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation J. Biol. Chem. 282(13),9323-9334(2007).

Properties of 17(S)-HDHA-d5

solubility

DMF: miscible; DMSO: miscible; Ethanol: miscible; PBS (pH 7.2): 0.8 mg/ml

Safety information for 17(S)-HDHA-d5

Computed Descriptors for 17(S)-HDHA-d5

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