Indeloxazine hydrochloride

Description

Indeloxazine hydrochloride is a nootropic indicated for the treatment of senile dementia. In animal models indeloxazine reportedly enhances brain energy metabolism and monoamine content; its claimed protective effect on ischemia-induced amnesia is supported by the prolonged step-through latency in passive avoidance tests.

Originator

Yamanouchi (Japan)

The Uses of Indeloxazine hydrochloride

Antidepressant.

brand name

Elen

Metabolic pathway

After oral administration of indeloxazine hydrochloride to rats, two conjugates, which are labile to a- glucosidase hydrolysis but refractory to b-glucosidase, are isolated from the urine and identified as a-D- glucopyranosides of trans-4-(2-morpholinylmethoxy)- 1,2-indandiol and trans-6-[[(1,2-dihydroxy-4- indanyl)oxy]-methyl]-3-morpholinone.