INCB28060 Dihydrochloride
- CAS NO.：1197376-85-4
- Empirical Formula: C23H18ClFN6O
- Molecular Weight: 448.89
- MDL number: MFCD30502991
- EINECS: 695-736-8
- Update Date: 2026-04-22 18:57:36
What is INCB28060 Dihydrochloride?
Description
INCB28060 Dihydrochloride is a novel, ATP-competitive inhibitor of c-MET kinase with an IC50 with 0.13 nM.
The Uses of INCB28060 Dihydrochloride
INCB28060 dihydrochloride exhibits picomolar enzymatic potency and is highly specific for c-MET with more than 10, 000-fold selectivity over a large panel of human kinases. This inhibitor potently blocks c-MET phosphorylation and activation of its key downstream effectors in c-MET-dependent tumor cell lines. As a result, INCB 28060 potently inhibits c-MET-dependent tumor cell proliferation and migration and effectively induces apoptosis in vitro.
Safety information for INCB28060 Dihydrochloride
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