IM-93

CAS NO.：1173657-73-2
Empirical Formula: C21H28N4O2
Molecular Weight: 368.47
Update Date: 2025-04-17 18:22:24

What is IM-93?

Description

IM-93 is a dual inhibitor of ferroptosis and NETosis.¹ It inhibits tert-butyl hydroperoxide- and erastin-induced ferroptosis in NIH3T3 cells (IC₅₀s =1.8 and 1.9 nM, respectively), as well as decreases NETosis and lipid peroxidation induced by phorbol 12-myristate 13-acetate (PMA; ) in isolated human peripheral blood neutrophils when used at concentrations ranging from 1.6 to 25 μM. IM-93 also inhibits hydrogen peroxide-induced necrosis in HL-60 cells (IC₅₀ = 0.45 μM), but has no effect on necroptosis induced by Fas ligand in combination with Z-VAD-FMK and cycloheximide in Jurkat cells or pyroptosis induced by S. aureus and P. aeruginosa in THP-1 cells when used at a concentration of 25 μM.

References

1. Dodo, K., Kuboki, E., Shimizu, T., et al. Development of a water-soluble indolylmaleimide derivative IM-93 showing dual inhibition of ferroptosis and NETosis ACS Med. Chem. Lett. 10(9),1272-1278(2019).

Properties of IM-93

Boiling point:	540.2±50.0 °C(Predicted)
Density	1.17±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 20mg/mL; DMSO: 20mg/mL; DMSO:PBS (pH 7.2) (1:2): 0.3mg/mL; Ethanol: 1mg/mL
form	A crystalline solid
pka	9.48±0.28(Predicted)

Safety information for IM-93

Computed Descriptors for IM-93

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