IDO/TDO-IN-1
- CAS NO.：2033173-01-0
- Empirical Formula: C25H24FN5
- Molecular Weight: 413.49
- MDL number: MFCD32174301
- Update Date: 2026-05-11 16:31:51
What is IDO/TDO-IN-1?
Description
IDO/TDO-IN-1 (compound 25) is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50s of 9.7 and 47 nM, respectively [1]. IC50: 9.7 nM (Indoleamine-2,3-dioxygenase), 47 nM (Tryptophan 2,3-dioxygenase)[1]
IDO/TDO-IN-1 inhibits IDO in the Hela cell line with an IC50 of 76 nM[1].
References
[1]. Tu W, et al. Discovery of Imidazoisoindole Derivatives as Highly Potent and Orally Active Indoleamine-2,3-dioxygenase Inhibitors. ACS Med Chem Lett. 2019 Jun 3;10(6):949-953.
Properties of IDO/TDO-IN-1
| Boiling point: | 664.5±55.0 °C(Predicted) |
| Density | 1.34±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| pka | 5.63±0.40(Predicted) |
| form | Solid |
| color | White to off-white |
Safety information for IDO/TDO-IN-1
Computed Descriptors for IDO/TDO-IN-1
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