IDH-889
- CAS NO.：1429179-07-6
- Empirical Formula: C23H25FN6O2
- Molecular Weight: 436.48
- Update Date: 2026-07-14 16:49:18
What is IDH-889?
Description
IDH889 is a potent and selective inhibitors of IDH1. IDH899 shows IDH (R132H) IC50 = 20 nM; Cell 2-HG IC50 = 14 nM. IDH889 demonstrates significantly improved plasma exposure in mice vs IDH662 (AUC 3.6 μM·h, Cmax 1.7 μM at 10 mg/kg; AUC 55.5 μM·h, Cmax 14.2 μM at 100 mg/kg). IDH889 also has excellent permeability and no efflux in the Caco-2 and human MDR1-MDCK cell lines, supporting the hypothesis that potent inhibition of mutant IDH1 function by binding at the allosteric binding site is compatible with brain penetration.
Properties of IDH-889
| Boiling point: | 589.5±60.0 °C(Predicted) |
| Density | 1.284±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO |
| form | Solid |
| pka | 4.15±0.10(Predicted) |
| color | White to off-white |
Safety information for IDH-889
Computed Descriptors for IDH-889
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