IDAZOXAN HYDROCHLORIDE
Synonym(s):(±)-2-[1,4-Benzodioxan-2-yl]-2-imidazoline hydrochloride;2-(1,4-Benzodioxan-2-yl)-2-imidazoline hydrochloride, RX781094, Idazoxa, α₂-Adrenoceptor Antagonist, Idazoxan Hydrochloride;Idazoxan Hydrochloride - CAS 79944-56-2 - Calbiochem;RX 781094
- CAS NO.：79944-56-2
- Empirical Formula: C11H13ClN2O2
- Molecular Weight: 240.69
- MDL number: MFCD00069293
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-12-05 14:33:18
What is IDAZOXAN HYDROCHLORIDE?
Chemical properties
mp 207-209°C
The Uses of IDAZOXAN HYDROCHLORIDE
Idazoxan hydrochloride has been used to study the efficacy of antidepressant treatments that interact with multiple neurotransmitter systems.
The Uses of IDAZOXAN HYDROCHLORIDE
An α-adrenoceptor antagonist; in rat brain Idazoxan is a pure antagonist and it has a selectivity for α2- over α1-receptors markedly superior to Piperoxane, Yohimbine, or Rauwolscine. Antiparkinsonian.
The Uses of IDAZOXAN HYDROCHLORIDE
Antiparkinsonian;Alpha2 agonist
What are the applications of Application
Idazoxan hydrochloride is an α2-AR adrenoceptor antagonist and I2 imidazoline receptor agonist.
Biological Activity
α 2 -adrenoceptor antagonist, and I 2 ligand, selective over I 1 sites (pK i values are 5.90, 7.22, 8.01, 7.43, and 7.7 for I 1 , I 2 , α 2A , α 2B , and α 2C receptors respectively).
Biochem/physiol Actions
α2-adrenoceptor antagonist; I2?imidazoline receptor agonist; I1?imidazoline receptor antagonist. Idazoxan can antagonize various behaviors generated by ethanol in a preclinical setting. It possesses neuroprotective activity against spinal cord injury, resulted due to experimental autoimmune encephalomyelitis (EAE) in mouse, an animal modal of multiple sclerosis (MS).
Properties of IDAZOXAN HYDROCHLORIDE
| Melting point: | 207-208° |
| storage temp. | Store at RT |
| solubility | H2O: 300 mg/mL |
| form | Powder |
| color | White to off-white |
| Water Solubility | Soluble to 100 mM in water |
| Stability: | Hygroscopic |
Safety information for IDAZOXAN HYDROCHLORIDE
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral |
| Precautionary Statement Codes |
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for IDAZOXAN HYDROCHLORIDE
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