IDAZOXAN HYDROCHLORIDE

Chemical properties

mp 207-209°C

The Uses of IDAZOXAN HYDROCHLORIDE

Idazoxan hydrochloride has been used to study the efficacy of antidepressant treatments that interact with multiple neurotransmitter systems.

The Uses of IDAZOXAN HYDROCHLORIDE

An α-adrenoceptor antagonist; in rat brain Idazoxan is a pure antagonist and it has a selectivity for α2- over α1-receptors markedly superior to Piperoxane, Yohimbine, or Rauwolscine. Antiparkinsonian.

The Uses of IDAZOXAN HYDROCHLORIDE

Antiparkinsonian;Alpha2 agonist

What are the applications of Application

Idazoxan hydrochloride is an α2-AR adrenoceptor antagonist and I2 imidazoline receptor agonist.

Biological Activity

α 2 -adrenoceptor antagonist, and I 2 ligand, selective over I 1 sites (pK i values are 5.90, 7.22, 8.01, 7.43, and 7.7 for I 1 , I 2 , α 2A , α 2B , and α 2C receptors respectively).

Biochem/physiol Actions

α2-adrenoceptor antagonist; I2?imidazoline receptor agonist; I1?imidazoline receptor antagonist. Idazoxan can antagonize various behaviors generated by ethanol in a preclinical setting. It possesses neuroprotective activity against spinal cord injury, resulted due to experimental autoimmune encephalomyelitis (EAE) in mouse, an animal modal of multiple sclerosis (MS).