ICA 069673
- CAS NO.：582323-16-8
- Empirical Formula: C11H6ClF2N3O
- Molecular Weight: 269.63
- MDL number: MFCD20926351
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-04-24 14:58:14
What is ICA 069673?
Description
ICA 069673 is a heteromeric Kv7 channel activator. It is selective for Kv7.2/7.3 over Kv7.3/7.5 (EC50s = 0.69 and 14.3 μM, respectively) and also activates Kv7.4, Kv7.5, and heteromeric Kv7.4/7.5 channels in a dose-dependent manner. ICA 069673 has no activity against hERG, Nav1.5, and Kv7.1 cardiac ion channels (IC50s = >30 μM). Oral administration of ICA 069673 increases latency to first tonic-clonic seizure in the rat maximal electroshock and pentylentetrazol-induced seizure models (ED50s = 1.5 and <1 mg/kg, respectively). Formulations containing ICA 069673 are under clinical investigation for the treatment of epilepsy.
What are the applications of Application
ICA 069673 is a selective activator of the KCNQ2/Q3 potassium channel
Storage
Room temperature
Properties of ICA 069673
| Boiling point: | 358.9±37.0 °C(Predicted) |
| Density | 1.539±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DNF:30.0(Max Conc. mg/mL);111.26(Max Conc. mM) DMSO:36.24(Max Conc. mg/mL);134.4(Max Conc. mM) Ethanol:30.25(Max Conc. mg/mL);112.18(Max Conc. mM) |
| form | Powder |
| pka | 9.47±0.70(Predicted) |
| color | White to off-white |
Safety information for ICA 069673
Computed Descriptors for ICA 069673
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