ICA 069673

CAS NO.：582323-16-8
Empirical Formula: C11H6ClF2N3O
Molecular Weight: 269.63
MDL number: MFCD20926351
SAFETY DATA SHEET (SDS)
Update Date: 2026-04-24 14:58:14

What is ICA 069673?

Description

ICA 069673 is a heteromeric K_v7 channel activator. It is selective for K_v7.2/7.3 over K_v7.3/7.5 (EC₅₀s = 0.69 and 14.3 μM, respectively) and also activates K_v7.4, K_v7.5, and heteromeric K_v7.4/7.5 channels in a dose-dependent manner. ICA 069673 has no activity against hERG, Na_v1.5, and K_v7.1 cardiac ion channels (IC₅₀s = >30 μM). Oral administration of ICA 069673 increases latency to first tonic-clonic seizure in the rat maximal electroshock and pentylentetrazol-induced seizure models (ED₅₀s = 1.5 and <1 mg/kg, respectively). Formulations containing ICA 069673 are under clinical investigation for the treatment of epilepsy.

What are the applications of Application

ICA 069673 is a selective activator of the KCNQ2/Q3 potassium channel

Storage

Room temperature

Properties of ICA 069673

Boiling point:	358.9±37.0 °C(Predicted)
Density	1.539±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	DNF:30.0(Max Conc. mg/mL);111.26(Max Conc. mM) DMSO:36.24(Max Conc. mg/mL);134.4(Max Conc. mM) Ethanol:30.25(Max Conc. mg/mL);112.18(Max Conc. mM)
form	Powder
pka	9.47±0.70(Predicted)
color	White to off-white

Safety information for ICA 069673

Computed Descriptors for ICA 069673

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