IB-MECA
Synonym(s):1-Deoxy-1-[6-[((3-Iodophenyl)methyl)amino]-9H-purin-9-yl]-N-methyl-β-D -ribofuranuronamide;N6-(3-Iodobenzyl)adenosine-5′-N-methyluronamide
- CAS NO.：152918-18-8
- Empirical Formula: C18H19IN6O4
- Molecular Weight: 510.29
- MDL number: MFCD00671785
- SAFETY DATA SHEET (SDS)
- Update Date: 2026-02-02 18:10:39
What is IB-MECA?
The Uses of IB-MECA
IB-MECA has been used for intraocular pressure and corneal thickness measurements in rabbits.
What are the applications of Application
IB-MECA is a potent and selective Adenosine A3-R agonist
Definition
ChEBI: A derivative of adenosine in which the 5'-hydroxymethyl group is replaced by N-ethylcarboxamido and one of the hydrogens of the exocyclic amino function is substituted by a 3-iodobenzyl group.
Biological Activity
Potent and selective A 3 adenosine receptor agonist (K i values are 1.1, 54 and 56 nM for A 3 , A 1 and A 2A receptors respectively). Cardioprotective, reduces infarct size upon reperfusion in rats.
Biochem/physiol Actions
Selective A3 adenosine receptor agonist.
Storage
Desiccate at +4°C
Properties of IB-MECA
| Density | 1.98±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | hot ethanol: >10 mg/mL |
| pka | 12.72±0.70(Predicted) |
| form | solid |
| color | white |
Safety information for IB-MECA
Computed Descriptors for IB-MECA
| InChIKey | HUJXGQILHAUCCV-MOROJQBDSA-N |
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![1-[6-[[(4-AMINO-3-IODOPHENYL)METHYL]AMINO]-9H-PURIN-9-YL]-1-DEOXY-N-METHYL-BETA-D-RIBOFURANURONAMIDE](https://img.chemicalbook.in/StructureFile/ChemBookStructure3/GIF/CB7278004.gif)
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