Hydrazinecarbothioamide, 2-[1-(3-bromophenyl)propylidene]-

CAS NO.：443144-54-5
Empirical Formula: C10H12BrN3S
Molecular Weight: 286.19
Update Date: 2025-08-06 15:14:14

What is Hydrazinecarbothioamide, 2-[1-(3-bromophenyl)propylidene]-?

Description

Bromo-PTC (443144-54-5) is a potent inhibitor of cruzain (IC50 = 100 nM). Cruzain is the major cysteine protease of Trypanosoma cruzi, the protozoan parasite responsible for American trypanosomiasis or Chagas’ disease. Cruzain is essential for the replication of the parasite and thus is a new target for antitrypanosomal chemotherapy. Bromo-PTC exhibits trypanocidal activity in cultured host cells without toxicity1.

References

1) Xaohui et al. (2002), Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain; J. Med. Chem., 45 2695

Properties of Hydrazinecarbothioamide, 2-[1-(3-bromophenyl)propylidene]-

Boiling point:	388.0±44.0 °C(Predicted)
Density	1.49±0.1 g/cm3(Predicted)
storage temp.	RT
solubility	Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 10 mg/ml).
pka	11.36±0.70(Predicted)
form	solid
color	White
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

Safety information for Hydrazinecarbothioamide, 2-[1-(3-bromophenyl)propylidene]-

Computed Descriptors for Hydrazinecarbothioamide, 2-[1-(3-bromophenyl)propylidene]-

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