Hydrazine acetate

Description

Hydrazine acetate is an acetate salt of hydrazine. It is used as a reagent to cleavage glycosidic esters and anomeric denitration of carbohydrates. In organic synthesis, it is also used as a building block to prepare various organic derivatives.

Chemical properties

white to light yellow adhering crystals or powder

The Uses of Hydrazine acetate

Hydrazine acetate has been used in preparation of:

• 2,3,5-tri-O-acetyl-α-L-arabinofuranosyl trichloroacetimidate
• disaccharide 4-methoxyphenyl glycoside

The Uses of Hydrazine acetate

suzuki reaction

Definition

Deformylation with hydrazine acetate was slower than that with hydrazine. Approximately 90% and 5% of the formyl group were removed at 50 and 20 °C, respectively, after 5 h. The rate of deformylation with hydrazine acetate is slower than that with hydrazine alone, but hydrazine acetate would be less harmful to a peptide when the peptide hydrazide is recovered from a formylated peptide hydrazide[1].

References

[1] K. Hojo. “Acylation of hydrazides with acetic acid and formic acid.” Chemical pharmaceutical bulletin 34 1 (2002): 140–2.