HUMAN PAI-1

Synonym(s):PAIE;PLANH1;Plasminogen activator inhibitor, β-migrating endothelial cell-derived type;Serpin E1 PAI-1;Serpine 1

CAS NO.：140208-23-7
Molecular Weight: 0
MDL number: MFCD01094930
Update Date: 2026-05-28 00:01:00

What is HUMAN PAI-1?

The Uses of HUMAN PAI-1

Plasminogen activator inhibitor 1 (PAI-1) human has been used:

as an inhibitor of pro-brain-derived neurotrophic factor (proBDNF) in radioimmunoprecipitation assay (RIPA) in peripheral blood and lymphocytes
to block plasmin activation in mice infected with C. albicans hyphae
to test its effect on neurite growth in neurons

General Description

Plasminogen activator inhibitor 1 (PAI-1) or serine protease inhibitor E1 (SERPINE1) gene is mapped to human chromosome 7q22.1. PAI-1 is produced in hepatocytes, endothelial cells, smooth muscle cells, megakaryocytes, and adipocytes.

Biochem/physiol Actions

Plasminogen Activator Inhibitor 1 (PAI-1) protein belongs to the Serpin superfamily of serine protease inhibitors. It is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), the activators of plasminogen and therefore inhibits the fibrinolysis process. PAI is involved in extracellular matrix remodeling and has been implicated in processes like angiogenesis, chemotaxis, ovulation, and embryogenesis. PAI-1 is present in increased levels in various disease states such as a number of cancer forms, obesity and the metabolic syndrome.

Properties of HUMAN PAI-1

storage temp.	-20°C
form	lyophilized powder

Safety information for HUMAN PAI-1

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for HUMAN PAI-1

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