HS-PEG5-CH2CH2COOH
- CAS NO.：1449390-67-3
- Empirical Formula: C13H26O7S
- Molecular Weight: 326.41
- MDL number: MFCD31580077
- Update Date: 2025-04-17 18:22:24
What is HS-PEG5-CH2CH2COOH?
Biological Activity
Thiol-PEG5-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Properties of HS-PEG5-CH2CH2COOH
| Boiling point: | 461.0±45.0 °C(Predicted) |
| Density | 1.150±0.06 g/cm3(Predicted) |
| pka | 4.28±0.10(Predicted) |
Safety information for HS-PEG5-CH2CH2COOH
Computed Descriptors for HS-PEG5-CH2CH2COOH
New Products
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